News / Uncategorized
How genetic editing targets specific areas…
How genetic editing targets specific areas…
August 21, 2023
Deep Genomics is developing an artificial intelligence (AI)-enhanced approach to genetic editing. Ultimately, Deep Genomics’ work could one day compete with CRISPR technology. And its approach is great for diseases that occur when a genetic mutation causes certain cells to produce the wrong proteins.
Deep Genomics can correct this simply by “turning off” those cells. Of course, specificity is key with gene editing since we don’t want any off-target changes. The good news is, Deep Genomics can target specific areas of our DNA for treatment. This happens through “steric blocking oligonucleotides.”
These are short stretches of DNA or RNA that attach to specific places in the patient’s RNA. With genetic editing technologies using RNA, the therapy can be steered to precise locations. To use a loose analogy, it’s like two unique pieces of a puzzle. The therapy is only delivered to the precise location where the RNA matches.
The therapy can then modify the way the cells process the RNA and create proteins. No permanent changes happen to the DNA. Here’s an illustration of the process:
As you can see from the left and right sides of the graphic, the DNA itself hasn’t changed. The genetic editing procedure just affects the protein output. And because of how it’s “coded,” the treatment clearly targets the intended genes. Off-target editing was a much larger concern five to seven years ago, when genetic editing technology was more of a theory. Today, it has already been proven to cure diseases like beta thalassemia and sickle cell disease, with many others in clinical trials now.
All these genetic editing therapies must go through the normal clinical trial process as defined by the U.S. Food and Drug Administration (FDA). And Phase 1 is specifically designed to determine safety and inform decisions regarding dosing levels for the Phase 2 portion of the trials. While I don’t expect many problems to be found, any issues with off-target editing will likely be discovered in the laboratory, even before a therapy advances to Phase 1 clinical trials.
What makes genetic editing technology so exciting is that it is the definition of precision medicine. It’s designed to be precise and go straight to its desired target instead of a therapy that affects the entire body like chemotherapy. So we won’t have to worry about turning any organs off when it comes to genetic editing.
Share this article:
More in Uncategorized:
Ultra Clean Holdings (UCTT) July 25, 2024, Earnings Call Summary
Future Price Projections Participants: Rhonda Bennetto – Senior Vice President, Investor Relations Jim Scholhamer – Chief Executive Officer Sheri Savage...
How genetic editing targets specific areas…
July 26, 2024
APPLE, MICROSOFT, NVIDIA PRICE TARGET 🎯
Short term, price targets for the top three S&P 500 holdings
Short term, price targets for the top three S&P 500 holdings The following are my price targets for the very...
![Trent Grinkmeyer in front of stock market with bull background](https://bestofusinvestors.com/uploads/2023/06/trent-e1687263019450-300x300.webp)
Trent Grinkmeyer
July 25, 2024
Nvidia's Stake in Serve Robotics: A Game-Changer for AI-Powered Delivery?
The tech world was buzzing last week when news broke that AI chip giant Nvidia owns a 10% stake in Serve Robotics, a company specializing in autonomous sidewalk delivery robots. This revelation sent Serve's stock soaring an impressive 233% over two days. But what does this mean for the future of AI-powered delivery, and should investors jump on board?
The tech world was buzzing last week when news broke that AI chip giant Nvidia owns a 10% stake in...
![Trent Grinkmeyer in front of stock market with bull background](https://bestofusinvestors.com/uploads/2023/06/trent-e1687263019450-300x300.webp)
Trent Grinkmeyer
July 24, 2024
The Commercial Real Estate Crash
Its Ripple Effect on the Banking System and The Stock Market
The commercial real estate market is on the verge of a significant downturn, potentially mirroring the infamous 2008 financial crisis....
How genetic editing targets specific areas…
July 23, 2024
The Democratization of Compute
A Paradigm Shift in Business and Investment Artificial Intelligence (AI) is undeniably transformative, poised to revolutionize the world as we...
![Kerry Grinkmeyer in a suit standing in front of a stock chart with a bull on it](https://bestofusinvestors.com/uploads/2023/07/kerry-300x300.webp)
Kerry Grinkmeyer
July 23, 2024
Are Google and Meta Heading for a Stock Price Slump?
As an investor, it's crucial to keep a keen eye on market trends and potential shifts that could impact major players. Today, I want to discuss two tech giants that have long been darlings of Wall Street: Google and Meta. While they've enjoyed impressive growth and dominance in their respective fields, there are signs that their stock prices might face some headwinds in the near future.
As an investor, it's crucial to keep a keen eye on market trends and potential shifts that could impact major...
![Trent Grinkmeyer in front of stock market with bull background](https://bestofusinvestors.com/uploads/2023/06/trent-e1687263019450-300x300.webp)
Trent Grinkmeyer
July 23, 2024